Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory standards. With respect to personal use, contemporary consumers of cannabis report (as accessed via meta-analysis of patient usage data) that anxiety (50%), depression/mood (34%) and pain (64%) are the most common reasons.

Cannabis has been found to be a modulator of anxiety, with recent data showing that it targets specific brain regions, including the medial prefrontal cortex, amygdaloid complex, bed nucleus of stria terminalis, and hippocampus. It also interacts with the CB1 receptor causing a calming effect on GABAergic and glutamatergic transmission.

In a 2014 study at Institute of Psychiatry in Rio de Janeiro, researchers discovered some of the means by which cannabis sativa helps anxiety. After examining the effects of cannabis sativa on rats, the researchers concluded cannabidiol (CBD) was effective as an antidepressant-like and anxiolytic-like compound.

Research has shown that CBD produces a calming effect in the central nervous system. In 2019, researchers conducted a large retrospective case series at a psychiatric clinic involving clinical application of CBD for anxiety and sleep complaints. The researchers charted monthly documentation of anxiety and sleep quality in 103 adult adults. At the 30 day mark, the researchers found that CBD was effective at reducing the symptoms of both anxiety and sleep disorders. In addition, CBD was found to be safe and well-tolerate.

Other studies suggest lower doses of CBD have a more anxiolytic effect than higher doses. In two different studies, lower doses of CBD were shown to be helpful for decreasing anxiety for people during public speaking events. Higher doses were not as effective.

In 2019, researchers conducted the first clinically-focused systematic review on the emerging medical application of cannabis across all major psychiatric disorders. The investigators concluded that cannabis was beneficial for a number of anxiety disorders, including social anxiety disorder and posttraumatic stress disorder (PTSD).

A similar study review looked at 11 studies that used cannabis for the management of PTSD symptoms in returned armed services veterans. The researchers found that cannabinoid use was associated with global improvements in PTSD symptoms, such as insomnia and nightmares. They found that substantial numbers of military veterans with PTSD use cannabis or derivative products to control PTSD symptoms, with some patients reporting benefits in terms of reduced anxiety and insomnia, and improved coping ability.

The proposed neurobiological mechanisms by which medicinal cannabis helps with PTSD are varied and mostly derived from animal research. There are high concentrations of endocannabinoid receptors in the prefrontal cortex, amygdala and hippocampus that have a role in fear acquisition and extinction. Research has shown that cannabis acts directly on these areas of the brain.

A 2014 survey of 170 patients at a medical cannabis dispensary in California evaluated the frequency of cannabis use for mental health purposes. The results showed that those with high PTSD scores were more likely to use cannabis to improve sleep and ability to cope, compared to those with low PTSD scores. What’s more, cannabis use frequency was greater among those with high PTSD scores.

A retrospective study analyzed PTSD symptoms collected during 80 psychiatric evaluations of patients applying to the New Mexico Medical Cannabis Program from 2009 to 2011. The examination revealed a greater than 75% reduction in PTSD scores in patients with PTSD who were using cannabis compared to when they were not using it.

As more states legalize marijuana, both for medicinal and recreational use, more people are turning to cannabis in hopes of managing anxiety, particularly PTSD. There may be several drawbacks with everyday use of cannabis. Several studies have found that long-term marijuana use can cause memory loss. Memory impairment can occur because THC alters one of the areas of the brain, the hippocampus, responsible for memory formation. THC can also have negative consequences on the brain’s motivation system. Because it can raise your heart rate, THC can make some people with anxiety even more anxious.

Although the main psychoactive constituent of cannabis is tetrahydrocannabinol (THC), the plant is known to contain more than 500 compounds, among them at least 113 cannabinoids. Cannabinoids are a group of closely related compounds that act on cannabinoid receptors, which are part of the endocannabinoid system found in cells that alter neurotransmitter release in the brain.

Randi Fredricks, Ph.D.


Lisboa SF, Gomes FV, Terzian AL, Aguiar DC, Moreira FA, Resstel LB et al. (2017). The endocannabinoid system and anxiety. Vitam Horm, 103, 193–279.

Kosiba JD, Maisto SA, Ditre JW. (2019). Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms: Systematic review and meta-analysis. Soc Sci Med, 233, 181-192.

de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, Machado S, Arias-Carrión O, Crippa JA, Zuardi AW, Nardi AE, Silva AC. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets, 13(6), 953-960.

Ruehle S, Rey AA, Remmers F, Lutz B. (2012). The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol (Oxford, UK), 26(1), 23–39.

Shannon S, Lewis N, Lee H, Hughes S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J, 23, 18–041.

Guimarães FS, Chiaretti TM, Graeff FG, Zuardi AW. (1990). Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology (Berl), 100(4), 558–559.

Bergamaschi MM, Queiroz RH, Chagas MH et al. (2011). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology, 36(6), 1219–1226.

Zuardi AW, Cosme RA, Graeff FG, Guimarães FS. (1993). Effects of ipsapirone andcannabidiol on human experimental anxiety. J Psychopharmacol, 7(1 Suppl), 82–88.

Sarris J, Sinclair J, Karamacoska D, Davidson M, Firth J. (2020). Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review. BMC Psychiatry, 20(1), 24.

Betthauser K, Pilz J, Vollmer LE. (2015). Use and effects of cannabinoids in military veterans with posttraumatic stress disorder. Am J Health-Syst Pharm, 72(15), 1279–1284.

Bonn-Miller MO, Babson KA, Vandrey R. (2014). Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Drug Alcohol Depend, 136, 162–165.

Greer GR, Grob CS, Halberstadt AL. (2014). PTSD symptom reports of patients evaluated for the New Mexico Medical cannabis Program. J Psychoactive Drugs, 46(1), 73–77.